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哈罗德•布伦纳

首席医务官 英国皇家放射医学协会会员

个人介绍

国际著名的肿瘤专家。在来中国之前,布伦纳教授任以色列舍巴癌症中心主任达35年,也曾任特拉维夫大学、康奈尔大学、及布朗大学的医学副教授。曾先后工作过的机构有英国伦敦皇家马斯登医院、美国纽约斯隆-凯特琳纪念医院、纽约医院、布朗大学、南非约翰内斯堡总医院、南非开普敦Groote Schuur医院、以色列舍巴医学中心、以及以色列大卫杜夫癌症中心。曾任英国皇家放射学院的常务理事。布伦纳教授现任上海百瑞肿瘤的首席医务官。

布伦纳教授每周前往上海肿瘤医院和瑞金医院进行会诊和疑难病例讨论,为广大癌症患者带去有效的放疗,同时为三甲医院的医生分享其在放疗领域逾四十年的经验。

 

967-2002

Director, Institute of Radiotherapy and Oncology
Sheba Medical Center, Tel Hashomer

1983-date

Associate Professor, Tel Aviv University, Ramat Aviv (section of Oncology and Radiation Medicine)

1987-1995

Chairman, Section of Oncology, Tel Aviv University

1973-2002

Examiner, Israel National Examination Board for Oncology

1987-1996

Chairman, Israel National Examination Board for Oncology

1990-2001

Member of council of The Israel Cancer Association Medical Superintendent of Sir Charles Clore Hostel for Cancer Patients

1999-2001

Member of the Committee on the Control of Cytotoxic Drugs, Ministry of Health Chairman, Appeals Committee, Ministry of Health.

2001-2002

Assist. Prof Radiation Oncology, Weill Med.School, Cornel U.

2002-date

Medical Director. Eshkol Community Medical Services. Israel

2010-date

Chief Medical Officer, ProMed Cancer Centers – Shanghai, China

教育、培训和许可证

1954

“A” level Cambridge Overseas Senior High School Certificate. Milton Senior School. Bulawayo, Rhodesia (Zimbabwe)

1960

M.B. Ch.B. University of Cape Town, South Africa

1961

Intern, Groote Schuur Hospital. Cape Town, South Africa

1962-1964

Registrar, Surgery Groote Schuur Hospital, Cape Town, South Africa

1964-1965

Registrar, Department of Radiation Therapy and Oncology. Newcastle General Hospital. Newcastle on Tyne, England

1966

Registrar, Department of Radiation Therapy and Oncology. Newcastle General Hospital. Newcastle on Tyne, England

1966-1967

Senior Registrar, Radiation Therapy and Oncology. Royal Marsden Hospital, London, England

1967

F.R.C.R. Royal College of Radiologists. London, England

1973

Visiting Fellow Radiation Oncologist, Department of Oncology. 
Johannesburg General Hospital. Johannesburg, South Africa

1975

Visiting Fellow, Department of Medical Oncology. Mt. Sinai Hospital, New York, USA

1979-1980

Visiting Clinical Professor in Radiation Medicine. Brown University, Providence, Rhode Island, USA

1985-1986

Visiting Scientist and Special Clinical Fellow. Memorial Sloan-Kettering Cancer Center. New York, New York, USA Assist. Prof.& Senior Radiotherapist, New York Hosp. Cornell U.

2001-2002

Medical Director, Eshkol Oncology Centers, Israel

研究,咨询委员会和顾问

 

Basic science and clinical research in hyperthermia

 

Clinical research into reactions of drugs and radiation

 

Clinical evaluation of new drugs

 

Clinical research into immunological parameters and immunotherapy of selected tumors

 

Research into interactions between radiation, hyperthermia and drugs on a clinical level

 

Research into interactions between radiation, hyperthermia and drugs at the Radiobiology Laboratory, Sheba Medical Center

1983-date

Wolfson Hospital, Tel Giborim, Holon

1974-2006

Assuta Hospital, Tel Aviv

2001-2003

Attending Radiation Oncologist at New York Presbyterian Hospital (Q) and Weill Medical School, Cornell University

2005-date

Rabin Med Center, Dept Rad Oncology

奖品和荣誉
 

Israel Cancer Association Awards

 

In aid of research in cancer

 

In aid of improving clinical services at Sheba Medical Center

1982

Ben Gurion Award: Research in Hyperthermia

1985

Wolfson Trust Award: Contribution to Israeli Medicine

1989

Joseph J Schiffer Exchange Visitor, PM Hosp.Toronto Ca.

1991

Sheba Prize: Excellence in Medicine

编辑和审阅

1.  期刊

 

Harefuah

 

Israel Journal of Medicine Sciences

 

Cancer Investigation – 1996

 

International Journal of Hyperthermia - 1995

 

Int. J. Rad. Onc. Biol. Phys. Geriatrics and Medicine Intelligence

2.  研究机构

 

Israel-American Binational Research Foundation

 

American-Israel Research foundation

 

Ministry of Health, Chief Scientific Office ICRETT Fellowships (UICC)

委员

Israel Society for Oncology and Radiotherapy

European Society for Therapeutic Radiology and Oncology

Fellow of the Royal College of Radiation Oncology (England)

American Society for Clinical Oncology

American Society for Therapeutic Radiation Oncology

Radiation Research Society (USA)

European Society for Cancer Research

European Society for Medical Oncology

刊物

1. [Two cases of metastatic trophoblastic disease] Koman T, Menczer J, Brenner HJ. Harefuah 1970;78:598-9.

2. Werner A, Har Kedar J, Chaitchik S, Brenner HJ. [Lead shot as a means of shielding in x ray therapy]. Harefuah 1971; 81:449-51.

3. Brenner HJ, Werner A, Kalifa J, Surkes M. A mobile caesium safe for afterloading intra uterine applicators. Br J Radiol 1972;45:703-5.

4. Izsak FC, Brenner HJ, Cohen Haddad R. [The early detection of cancer]. Harefuah 1972 ; 83:596-8.

5. Izsak FC, Brenner HJ, Cohen Haddad R. The validity of an early cancer detection center. Isr J Med Sci 1972;8:972-7.

6. Izsak FC, Brenner HJ, Landes E, Ran M, Witz IP. Correlation between clinico pathological features of malignant tumors and cell surface immunoglobulins. Isr J Med Sci 1974;10:642-6.

7. Izsak FC, Brenner HJ, Medalie J. Screening for early detection: incidence and findings in rural settlements over eight years. Prev Med 1974 ; 3:142-53.

8. Izsak FC, Feller BA, Brenner HJ, Medalie J, Tugendreich J. [Assessment of the quality of life of the breast cancer patient]. Harefuah 1975; 89:445-8.

9. Brenner HJ, Yerushalmi A. Combined local hyperthermia and x irradiation in the treatment of metastatic tumours. Br J Cancer 1976;33:91-5.

10. Werner A, Brenner HJ. [The danger of radiation to the fetus]. Harefuah 1977;92:572-4.

11. Berkowicz M, Rath P, Aghai E, Many A, Ben Bassat I, Hulu N, Ramot B, Brenner H. Selective splenectomy in Hodgkin's disease, stages I and II. Results of treatment. Isr J Med Sci 1978;14:1275-82.

12. Aghai E, Hertz M, Ramot B, Brenner HJ. Hodgkin's disease of the lung. Isr J Med Sci 1978;14:1019-25.

13. Keydar I, Chen L, Karby S, Weiss FR, Delarea J, Radu M, Chaitcik S, Brenner HJ. Establishment and characterization of a cell line of human breast carcinoma origin. Eur J Cancer 1979;15:659-70.

14. Leith JT, Brenner HJ, DeWyngaert JK, Dexter DL, Calabresi P, Glicksman AS. Selective modification of the X ray survival response of two mouse mammary adenocarcinoma sublines by N,N dimethylformamide. Int J Radiat Oncol Biol Phys 1981;7:943-7.

15. Prager A, Ben Hur E, Chaitchik S, Brenner HJ, Riklis E. Characterization of the response of a human breast carcinoma cell line (T 47D) to radiation and chemotherapeutic agents. Isr J Med Sci 1981;17:976-9. ,

16. Menczer J, Baitner S, Modan M, Chaitchik S, Brenner H. Response to second line chemotherapy in ovarian cancer of epithelial origin. Eur J Cancer Clin Oncol 1981;17:1259-62.

17. Brenner HJ, Leith JT, DeWyngaert JK, Dexter DL, Calabresi P, Glicksman AS. Protection against hyperthermic cell killing of mouse mammary adenocarcinoma cells in vitro by N,N dimethylformamide. Radiat Res 1981;88(2): 291-8.

18. Tichler TE, Am YB, Brenner HJ. Chemotherapy in osteogenic sarcoma. Prog Clin Biol Res 1982; 99:49-75.

19. Brenner J, Brenner HJ. Radiotherapy of osteogenic sarcoma. Prog Clin Biol Res 1982; 99:77-81.

20. Leith JT, Brenner HJ, Bliven SF, Dexter DL, Calabresi P, Glicksman AS. Modification of the response of mouse skin to x irradiation by a polar solvent, N,N dimethylformamide. Int J Radiat Oncol Biol Phys 1982; 8:937-9.

21. Zhigun L, Werner A, Brenner HJ. Determination of body outline by stereo x ray photogrammetry. Phys Med Biol 1982;27:743-7.

22. Werner A, Hayat H, Har Kedar Y, Brenner HJ. Prophylactic low dose post operative orthovoltage radiotherapy in stage II breast cancer. Br J Radiol 1983;56:945-8.

23. Menczer J, Atlas M, Werner A, Chaitchik S, Herzberg A, Rath P, Brenner H. Survival data of Israeli Jewish patients with squamous cell carcinoma of the cervix treated by irradiation. Gynecol Obstet Invest 1983;15:141-6.

24. Brenner J, Brenner HJ. [The treatment of cancer by anthracyclines (editorial)]. Harefuah 1983;104:205-7.

25. Brenner HJ, Bibi C, Chaitchik S. Adjuvant therapy for Dukes C adenocarcinoma of colon. Int J Radiat Oncol Biol Phys 1983; 9:1789-92.

26. Solomon A, Brenner HJ, Rubinstein Z, Chaitchik S, Morag B. Computerized tomography in ovarian cancer. Gynecol Oncol 1983;15:48-55.

27. Azizi E, Brenner HJ, Shoham J. Postsurgical adjuvant treatment of malignant melanoma patients by the thymic factor thymostimulin. Arzneimittelforschung 1984; 34:1043-7.

28. Menczer J, Ben Baruch G, Modan M, Brenner J, Brenner H. A comparison of postoperative radiotherapy with postoperative chemotherapy in stage II IV ovarian cancer patients. Gynecol Oncol 1984;17:207-12.

29. Menczer J, Brenner H. [Intraperitoneal Chemotherapy a new treatment method of ovarian cancer patients]. Harefuah 1985;109:202-4.

30. Hercbergs A, Werner A, Brenner HJ. Reduced thoracic vertebrae metastases following post mastectomy parasternal irradiation. Int J Radiat Oncol Biol Phys 1985;11:773-6.

31. Kashtan H, Birkenfeld S, Rath P, Brenner HJ, Krispin M. Prophylactic oophorectomy in premenopausal women with stage II breast carcinoma. J Surg Oncol 1986;31:184-7.

32. Menczer J, Brenner J, Modan M, Ben Baruch G, Brenner H. A comparison of low and high dose cisplatin based combination chemotherapy as initial postoperative treatment in advanced ovarian adenocarcinoma. Am J Obstet Gynecol 1986;155:974-9.

33. Menczer J, Modan M, Brenner J, Ben Baruch G, Brenner H. Abdominopelvic irradiation for stage II IV ovarian carcinoma patients with limited or no residual disease at second look laparotomy after completion of cisplatinum based combination chemotherapy. Gynecol Oncol 1986;24:149-54.

34. Robinson E, Brenner H. [Oncology in Israel, whither? (editorial)]. Harefuah 1987;113:86-7.

35. Kutcher GJ, Kestler C, Greenblatt D, Brenner H, Hilaris BS, Nori D. Technique for external beam treatment for mesothelioma. Int J Radiat Oncol Biol Phys 1987;13:1747-52.

36. Tichler T, Ramon Y, Rath P, Hendler S, Brenner HJ. Neoadjuvant chemotherapy in early stage and locally advanced small bulk squamous cell carcinoma of the oral cavity and oropharynx. Isr J Med Sci 1988;24:539-44.

37. Hercbergs AA, Tadmor R, Findler G, Sahar A, Brenner H. Hypofractionated radiation therapy and concurrent cisplatin in malignant cerebral gliomas. Rapid palliation in low performance status patients. Cancer 1989;64:816-20.

38. Menczer J, Ben Baruch G, Modan M, Brenner H. Second look laparotomy in ovarian carcinoma patients after 8 and after 12 courses of cisplatin based chemotherapy. Gynecol Obstet Invest 1989;27:102-4.

39. Menczer J, Ben Baruch G, Modan M, Brenner H. Intraperitoneal cisplatin chemotherapy versus abdominopelvic irradiation in ovarian carcinoma patients after second look laparotomy. Cancer 1989; 63:1509-13.

40. Hirsh A, Alhalel A, Weiss A, Brenner H, Avni I. Bilateral total corneal epithelial erosion as a side effect of cytotoxic therapy. Br J Ophthalmol 1990;74:638.

41. Shoham J, Hirsch R, Zakay Rones Z, Osband ME, Brenner HJ. Augmentation of tumor cell immunogenicity by viruses an approach to specific immunotherapy of cancer. Nat Immun Cell Growth Regul 1990; 9:165-72.

42. Bank I, Roth D, Book M, Guterman A, Shnirrer I, Block R, Ehrenfeld M, Langevitz P, Brenner H, Pras M. Expression and functions of very late antigen 1 in inflammatory joint diseases. J Clin Immunol 1991;11:29-38,

43. Menczer J, Ben Baruch G, Rizel S, Brenner H. Acute renal failure associated with intraperitoneal cisplatin chemotherapy with systemic thiosulfate protection in ovarian cancer patients. Eur J Gynaecol Oncol 1991;12:403-6,

44. Kutcher GJ, Fuks Z, Brenner H, Brown AP, Burman C, Cheng E, Coia L, Krippner K, Manolis JM, Mohan R, et al. Three dimensional photon treatment planning for carcinoma of the nasopharynx. Int J Radiat Oncol Biol Phys 1991;21:169-82,

45. Coia L, Galvin J, Sontag M, Blitzer P, Brenner H, Cheng E, Doppke K, Harms W, Hunt M, Mohan R, et al. Three dimensional photon treatment planning in carcinoma of the larynx. Int J Radiat Oncol Biol Phys 1991;21:183-92.

46. Beitler JJ, Fass DE, Brenner HA, Huvos A, Harrison LB, Leibel SA, Fuks Z. Esthesioneuroblastoma: is there a role for elective neck treatment? Head Neck 1991;13:321-6.

47. Mandel M, Toren A, Findler G, Neumann Y, Kende G, Faibel M, Tadmor R, Brenner H, Sahar A, Ramot B, et al. The management of pediatric brain tumors in a tertiary center. Med Oncol Tumor Pharmacother 1992; 9:159-64.

48. Menczer J, Ben Baruch G, Rizel S, Brenner H. Intraperitoneal chemotherapy versus no treatment in patients with ovarian carcinoma who are in complete clinical remission. Cancer 1992;70:1956-9.

49. Menczer J, Ben Baruch G, Rizel S, Brenner H. Cisplatin in combination with continuous VP16 infusion as second line chemotherapy in ovarian carcinoma. A pilot study. Eur J Gynaecol Oncol 1992;13:316-8.

50. Menczer J, Ben Baruch G, Rizel S, Brenner H. Intraperitoneal cisplatin chemotherapy in ovarian carcinoma patients who are clinically in complete remission. Gynecol Oncol 1992;46:222-5.

51. Hercbergs A, Brok Simoni F, Holtzman F, Bar Am J, Leith JT, Brenner HJ. Erythrocyte glutathione and tumour response to chemotherapy. Lancet 1992;339:1074-6.

52. Baram J, Tichler T, Nass D, Brenner HJ. Extraskeletal Ewing’s Sarcoma. Harefuah. 1992 Jan. 1;122(1):12-5. Hebrew.

53. Bank I, Book M, Huszar M, Baram Y, Schnirer I, Brenner H. V delta 2+ gamma delta T lymphocytes are cytotoxic to the MCF 7 breast carcinoma cell line and can be detected among the T cells that infiltrate breast tumors. Clin Immunol Immunopathol 1993;67:17-24.

54. Ben Baruch G, Menczer J, Feldman B, Rizel S, Brenner H. Intraperitoneal cisplatin chemotherapy versus abdominopelvic irradiation in ovarian carcinoma patients after second look laparotomy. A reassessment based on mature data. Eur J Gynaecol Oncol 1994;15272-6.

55. Azizi E, Friedman J, Pavlotsky F, Iscovich J, Bornstein A, Shafir R, Trau H, Brenner H, Nass D. Familial cutaneous malignant melanoma and tumors of the nervous system. A hereditary cancer syndrome. Cancer 1995;761571-8.

56. Zwas ST, Goshen E, Rath P, Brenner H, Klein E, Ben Ari G. Detection efficiency of colorectal carcinoma recurrence using technetium pertechnetate anti carcinoembryonic antigen monoclonal antibody BW 431/26. Cancer 1995;76:215-22.

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